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Commonly Reported Reactions to Clobetasol Propionate

Reported Side Effects

The reported clobetasol propionate side effects vary, depending on the particular form of the medication being used, even though all of the products contain the same active ingredient in the same strength. The difference in reactions is due to the different inactive ingredients in the various products. For instance, alcohol-based products usually cause more stinging or burning than nonalcohol-based products.
 
In clinical trials, the most common side effects of clobetasol propionate shampoo (Clobex) included:
 
  • Skin discomfort -- in up to 4.7 percent of people
  • Headaches -- up to 1.8 percent.
 
For clobetasol propionate lotion (Clobex), the most commonly reported side effects included:
 
  • Weakening and thinning of the skin -- in up to 4.2 percent of people
  • Spider veins -- up to 3.2 percent
  • Skin discomfort -- up to 1.3 percent
  • Dry skin -- up to 1 percent.
 
In studies, the most common side effects of clobetasol propionate spray (Clobex) included:
 
  • Burning sensation at the application site -- in up to 40 percent of people
  • Upper respiratory tract infection (such as the common cold) -- up to 8 percent
  • Itching at the application site -- up to 3 percent
  • Asteatotic eczema (a type of eczema that involves very dry skin that appears cracked in an unusual pattern) -- up to 2 percent
  • Dry skin -- up to 2 percent.
 
In clinical trials, the most common reactions to the regular clobetasol propionate foam (Olux) included:
 
  • Suppression of the adrenal glands -- in up to 100 percent of people
  • Burning -- up to 10 percent
  • Other skin reactions (not specified) -- up to 4 percent.
 
Adrenal suppression (also known as HPA suppression) is serious but usually reversible. The high rate of suppression (100 percent) was seen in studies of clobetasol propionate foam for atopic dermatitis of the body, a condition for which the medication is not approved.
 
For clobetasol propionate emollient foam (Olux-E), the most commonly reported side effects included:
 
  • Suppression of the adrenal glands -- in up to 16.2 percent of people
  • Weakening and thinning of the skin -- up to 1.9 percent
  • Skin reactions -- up to 1.6 percent.
 
Less information is available for Temovate and Cormax products (cream, emollient cream, ointment, gel, and scalp application), as they are relatively older medications. The most commonly reported side effect of these products is burning or stinging, which was reported in up to 5 to 10 percent of people. Fluid-filled, acne-like bumps were also relatively common, occurring in up to 1 percent of people using the scalp solution.
 

Clobetasol Propionate Drug Information

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