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Reported and Common Reactions to Clobetasol Propionate Foam

Clobetasol Propionate Foam Side Effects to Report

Some side effects of steroids, including clobetasol propionate foam, are potentially serious and should be reported immediately to your healthcare provider. In addition to the HPA suppression side effects discussed previously, these include, but are not limited to:
  • High blood pressure (hypertension)
  • High blood sugar levels (hyperglycemia) or diabetes
  • Infections
  • Ruptured tendons
  • Psychotic reactions, such as hallucinations or extreme aggression
  • Glaucoma
  • Severe fluid retention
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Difficulty breathing or swallowing.
In general, these serious reactions are unlikely to occur when clobetasol propionate foam is used as directed for a short period of time (two weeks or less). Applying too much of the medicine over too large an area, for an extended period of time, may increase the risk for serious steroid side effects.

Common Side Effects

Clobetasol propionate foam has been studied extensively in clinical trials. In these studies, one group of people received clobetasol propionate foam, while another group was given a placebo (a similar product that does not contain any active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
The reported side effects in these studies varied, depending on the particular form of clobetasol propionate foam (regular foam or alcohol-free emollient foam). The most common side effect of the regular clobetasol propionate foam included:
  • Suppression of the adrenal glands -- in up to 100 percent of people
  • Burning -- up to 10 percent
  • Other skin reactions (not specified) -- up to 4 percent.
HPA suppression is serious but usually reversible. The high rate of suppression (up to 100 percent) was seen in studies of clobetasol propionate foam for atopic dermatitis of the body, a condition for which the medication is not approved.
For clobetasol propionate emollient foam, the most commonly reported side effects included:
  • Suppression of the adrenal glands -- in up to 16.2 percent of people
  • Weakening and thinning of the skin -- up to 1.9 percent
  • Skin reactions -- up to 1.6 percent.
In general, side effects are more common when a dressing, such as a bandage, is used to cover the medication. Do not use a dressing, unless your healthcare provider specifically recommends that you do so.

Clobetasol Propionate Foam Information

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