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Drug Interactions With Clindamycin/Benzoyl Peroxide

As a topical acne medication, clindamycin/benzoyl peroxide is known to interact with other topical acne products. Combining these medicines can result in severe skin irritation, so talk to your healthcare provider if you are using any other acne products. Other drugs that can react with this medication include erythromycin and neuromuscular-blocking medications.

An Overview of Clindamycin/Benzoyl Peroxide Interactions

Clindamycin/benzoyl peroxide (Acanya®, BenzaClin®, Duac®) is a topical acne medicine that is available by prescription only. It can potentially react with a few other medicines. Some of the drugs that may lead to interactions with clindamycin/benzoyl peroxide include but are not limited to:
  • Erythromycin, especially erythromycin skin products, such as Akne-mycin®, Benzamycin®, Benzamycin® Pak, and Erythra-Derm™
  • Neuromuscular-blocking medications, such as:
    • Atracurium
    • Cisatracurium (Nimbex®)
    • Pancuronium
    • Rocuronium (Zemuron®)
    • Succinylcholine (Anectine®, Quelicin®)
    • Vecuronium (Norcuron®)

Drug Interactions With Clindamycin/Benzoyl Peroxide Explained

The following sections explain in detail the potentially negative reactions that can occur when clindamycin/benzoyl peroxide is combined with any of the drugs listed above.
Clindamycin (one of the active ingredients in clindamycin/benzoyl peroxide) may make erythromycin less effective. In general, these medications should not be used together. If your healthcare provider recommends erythromycin while using clindamycin/benzoyl peroxide, he or she may need to monitor you more closely to make sure erythromycin is working to treat your infection.

Clindamycin/Benzoyl Peroxide Information

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