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Cinryze Warnings and Precautions

By discussing your medical history and current medications with your healthcare provider before starting treatment with Cinryze, you can help minimize potentially dangerous complications. Safety precautions with Cinryze include warnings of potentially severe allergic reactions and an increased risk for heart attacks and strokes. Also, women who are pregnant may not be able to use this medicine.

 

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Cinryze® (C1 esterase inhibitor) if you have:
   
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
 
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Precautions and Warnings for Cinryze

Some warnings and precautions to be aware of prior to using this medication include the following:
 
  • Cinryze can cause a severe, life-threatening allergic reaction. The symptoms may be similar to those seen with hereditary angioedema (HAE), the condition the drug is used to treat. Stop treatment and seek immediate medical attention if you develop signs of an allergic reaction during or after your injection, such as:
    • Rash
    • Hives
    • Chest tightness
    • Wheezing or trouble breathing
    • Dizziness or faintness
    • Swelling of the face, lips, tongue, or throat.
 
  • Cinryze may increase the risk for blood clots and strokes, especially when used in higher-than-recommended doses. Seek immediate medical attention if you develop signs of a stroke or blood clot, such as:
    • Chest pain or pressure
    • Pain, warmth, or swelling in one or both legs
    • Sudden weakness or numbness, especially on one side of the body
    • A sudden, severe headache
    • Sudden confusion
    • Difficulty speaking or understanding speech
    • Problems with vision
    • Difficulty breathing.
 
  • Because Cinryze is made from human blood, it may contain infectious agents, such as viruses or the agent that causes Creutzfeldt-Jakob disease (CJD), a rare brain disease.
 
  • Talk to your healthcare provider before traveling. You will need to plan to bring enough Cinryze for your treatment while you are away.
   
  • Cinryze is a pregnancy Category C medication, which means it may not be safe for use when pregnant, although the full risks are currently unknown (see Cinryze and Pregnancy).
 
  • It is not known whether Cinryze passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to using the drug (see Cinryze and Breastfeeding).
 

Cinryze Medication Information

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