You should talk with your healthcare provider prior to using brimonidine gel if you have:
- Raynaud's syndrome
- Chest pain or other heart problems
- Ever had a stroke or mini-stroke
- Orthostatic hypotension (low blood pressure when changing positions)
- Thromboangiitis obliterans (a condition that causes multiple clots in the hands and feet)
- Sjögren's syndrome
- Have any allergies, including to medications, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Mirvaso and Pregnancy)
- Breastfeeding (see Mirvaso and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Brimonidine Gel to learn more, including information on who should not use the drug.)
Brimonidine gel is an alpha-2 adrenergic agonist. It works by activating alpha-2 adrenergic receptors, causing blood vessels of the face to constrict (narrow). This constriction causes an immediate but temporary reduction in redness.
In one clinical study, 22 percent to 31 percent of people who applied brimonidine gel had a 2-grade improvement on both a self-assessment and a professional assessment of their rosacea symptoms. In comparison, 9 percent to 11 percent of people who applied a placebo gel (with no active ingredient) had a similar improvement.
Improvements are seen immediately in the first day, and the effects typically last at least 12 hours.