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Common Reactions to Botulinum Toxin Type A

Common Side Effects of Botulinum Toxin Type A

Botulinum toxin type A has been studied thoroughly in clinical trials. In these studies, the side effects that occur in a group of people taking the drug are documented and are then compared to side effects that occur in another group of people not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
 
In studies of botulinum toxin type A for cosmetic use (to improve the appearance of lines between the eyebrows), common side effects included:
 
  • Droopy eyelids -- in up to 3 percent of people
  • Nausea -- up to 3 percent
  • Muscle weakness -- up to 2 percent
  • Facial pain -- up to 2 percent
  • Indigestion or heartburn -- up to 1 percent
  • Tooth problems -- up to 1 percent
  • High blood pressure (hypertension) -- up to 1 percent.
     
In studies of botulinum toxin type A for treating medical conditions, rather than for cosmetic purposes, the following common side effects of botulinum toxin type A were reported:
 
  • Droopy eyelids -- in up to 20.8 percent of people
  • Difficulty swallowing -- up to 19 percent
  • Vertical misalignment of the eye (vertical deviation) -- up to 16.9 percent
  • Upper respiratory infection (such as the common cold) -- up to 12 percent
  • Neck pain -- up to 11 percent
  • Headache -- up to 11 percent.
     
Other common side effects (occurring in 2 to 10 percent of people) included:
 
  • Cough
  • Flu-like symptoms, such as a fever and chills
  • Back pain
  • Runny or stuffy nose
  • Dizziness
  • Soreness at the injection site
  • Weakness
  • Dry mouth
  • Drowsiness
  • Bleeding at the injection site
  • Infection
  • Sore throat
  • Anxiety.
 

Botulinum Toxin Type A (Botox Cosmetic)

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