Drug Interactions With Botulinum Toxin Type A

Drug interactions with botulinum toxin type A may occur if the drug is combined with aminoglycoside antibiotics or neuromuscular-blocking medications, among other things. This can increase your risk of side effects, increase the effectiveness of botulinum toxin type A, or have other effects. To prevent drug interactions with botulinum toxin type A, tell your healthcare provider about all medications you take, including non-prescription drugs.

 

Drug Interactions With Botulinum Toxin Type A: An Overview

Botulinum toxin type A (Botox®) can potentially interact with a few other medicines. Some of the medications that may lead to drug interactions with botulinum toxin type A include:
 
  • Aminoglycoside antibiotics, such as:
     
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin
 
  • Botulinum toxin type B (Myobloc®)
     
  • Neuromuscular-blocking medications, such as:
     
    • Atracurium
    • Cisatracurium (Nimbex®)
    • Doxacurium (Nuromax®)
    • Mivacurium (Mivacron®)
    • Pancuronium
    • Rocuronium (Zemuron®)
    • Succinylcholine (Anectine®, Quelicin®)
    • Tubocurarine
    • Vercuronium (Norcuron®).
 

More Information on Botulinum Toxin Type A Interactions

The following sections explain in detail the potentially negative interactions that can occur when botulinum toxin type A is combined with any of the drugs listed above.
(Drug Interactions With Botulinum Toxin Type A Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;