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Drug Interactions With Botulinum Toxin Type A

Drug interactions with botulinum toxin type A may occur if the drug is combined with aminoglycoside antibiotics or neuromuscular-blocking medications, among other things. This can increase your risk of side effects, increase the effectiveness of botulinum toxin type A, or have other effects. To prevent drug interactions with botulinum toxin type A, tell your healthcare provider about all medications you take, including non-prescription drugs.

Drug Interactions With Botulinum Toxin Type A: An Overview

In 2009, the generic name for Botox was changed from "botulinum toxin type A" to "onabotulinumtoxinA." This was done to prevent confusion between Botox® and Dysport® (abobotulinumtoxinA), a new botulinum toxin type A product.
We are no longer updating the information on botulinum toxin type A found in this article. Instead, you can click OnabotulinumtoxinA or AbobotulinumtoxinA to read up-to-date information on these medicines.


Botulinum toxin type A (Botox®) can potentially interact with a few other medicines. Some of the medications that may lead to drug interactions with botulinum toxin type A include:
  • Aminoglycoside antibiotics, such as:
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin
  • Botulinum toxin type B (Myobloc®)
  • Neuromuscular-blocking medications, such as:
    • Atracurium
    • Cisatracurium (Nimbex®)
    • Doxacurium (Nuromax®)
    • Mivacurium (Mivacron®)
    • Pancuronium
    • Rocuronium (Zemuron®)
    • Succinylcholine (Anectine®, Quelicin®)
    • Tubocurarine
    • Vecuronium (Norcuron®).

Botulinum Toxin Type A (Botox Cosmetic)

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