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Precautions and Warnings With Adapalene/Benzoyl Peroxide

Before using adapalene/benzoyl peroxide, there are many precautions to be aware of, including warnings relating to who should not use the medication and possible side effects that may occur. For example, this prescription acne medication may increase your sensitivity to the sun and may not be safe for use in people who have eczema, a sunburn, or certain allergies.

What Should I Tell My Healthcare Provider Before Using Adapalene/Benzoyl Peroxide?

You should talk with your healthcare provider prior to using adapalene/benzoyl peroxide (Epiduo®) if you have:
  • Eczema
  • A sunburn
  • Sensitivity to the sun or go out in the sun often
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including other prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Adapalene/Benzoyl Peroxide Precautions and Warnings

Some of the warnings and precautions to be aware of include the following:
  • Adapalene/benzoyl peroxide should not be applied to cuts, scrapes, sores, eczema, or sunburned skin.
  • Your skin will be more sensitive to the sun while you are using adapalene/benzoyl peroxide. For this reason, you should avoid exposure to the sun and to artificial sun, including sunlamps and tanning beds, when you use this medication. If you do go out in the sun, use a sunscreen and protective clothing, such as a hat. Your healthcare provider can recommend an appropriate sunscreen for your skin type.
  • Your skin may be more sensitive to the wind or cold while you are using adapalene/benzoyl peroxide. Talk to your healthcare provider if your skin becomes extremely irritated from the wind or cold.
  • If you get a sunburn in an area of the skin where you normally apply adapalene/benzoyl peroxide, stop using the medication until your sunburn heals.
  • Adapalene/benzoyl peroxide can cause your skin to become dry. If your skin becomes too dry, try using a moisturizer.
  • Any area of the skin treated with adapalene/benzoyl peroxide should not be waxed, as this may cause skin damage and irritation.
  • Do not use adapalene/benzoyl peroxide more often than prescribed, as this may increase your risk for skin irritation.
  • Adapalene/benzoyl peroxide is unlikely to interact with other medications. However, using adapalene/benzoyl peroxide with some skin care products can increase your risk for skin irritation or dryness (see Drug Interactions With Adapalene/Benzoyl Peroxide).
  • Adapalene/benzoyl peroxide is considered a pregnancy Category C medication. This means that it may not be safe to use during pregnancy. Talk with your healthcare provider about the risks and benefits of using adapalene/benzoyl peroxide during pregnancy (see Epiduo and Pregnancy).
  • It is not known if adapalene/benzoyl peroxide passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, talk to your healthcare provider about using this medication (see Epiduo and Breastfeeding).

Adapalene/Benzoyl Peroxide Drug Information

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