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Treatment Instructions for Adapalene/Benzoyl Peroxide

When and How to Use This Medication

Some general considerations for when and how to use adapalene/benzoyl peroxide include the following:
  • This medication comes in the form of a gel. It is applied in a thin layer to the affected areas of the skin once a day.
  • Adapalene/benzoyl peroxide can be used in the morning or evening.


  • Wash your face and/or other affected areas, such as the back or chest, with a mild, soap-free cleanser and pat dry before applying adapalene/benzoyl peroxide.


  • Avoid the sensitive area around the eyes, lips, and mouth when applying this medication.
  • Do not apply more than a small amount or use this medication more than once a day. A pea-sized amount on the affected areas should be sufficient. Using too much of this medicine increases the risk of skin irritation, without increasing its effectiveness.
  • Avoid excessive sun exposure when you use adapalene/benzoyl peroxide, as you will burn more easily. If you do go out in the sun, make sure to use sunscreen and protective clothing, such as a hat.
  • Adapalene/benzoyl peroxide can bleach hair or colored fabric, so try to avoid contact with clothing.
  • For the medication to work properly, it must be used as prescribed.

Storage Information

Adapalene/benzoyl peroxide should be stored at room temperature, away from light, moisture, and heat. Keep the tube tightly closed. Keep this and all other medications out of the reach of children.

Is There a Generic Adapalene/Benzoyl Peroxide?

This medication is not available in generic form (see Generic Epiduo for more information).

Adapalene/Benzoyl Peroxide Drug Information

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