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More Info on Adapalene/Benzoyl Peroxide

Overdose Information

Applying too much adapalene/benzoyl peroxide can cause skin irritation, such as redness, burning, peeling, and discomfort. Taking this medication by mouth may cause symptoms of a vitamin A overdose.
If you have used too much, or have taken this medication by mouth, seek immediate medical attention.
(Click Epiduo Overdose for more information.)

What Should I Do If I Miss a Dose of Adapalene/Benzoyl Peroxide?

If you forget to apply adapalene/benzoyl peroxide one day, just skip that day and start again the next day.

How Does It Work?

Adapalene/benzoyl peroxide contains a combination of two acne medications:
  • Adapalene (Differin®) -- a retinoid
  • Benzoyl peroxide.
Retinoids are chemically related to vitamin A. Some other well-known retinoids include Retin-A® and Accutane®.
Retinoids are thought to work by suppressing inflammation and slowing down the rapid growth of skin cells. Benzoyl peroxide is thought to kill acne-causing bacteria, and to help soften and remove the outer layer of the skin. By combining these two medications, adapalene/benzoyl peroxide treats current pimples while also helping to prevent new ones from occurring.

Clinical Effects of Adapalene/Benzoyl Peroxide

In clinical studies, adapalene/benzoyl peroxide was shown to improve acne in people age 12 years old and older. In these studies, people with acne were given one of the following products to use for 12 weeks:
  • Adapalene/benzoyl peroxide
  • Adapalene alone
  • Benzoyl peroxide alone
  • A "placebo" gel that did not contain any active ingredients.
Most of the people in the studies had moderate acne to start with, which means they had pimples on over half of their face. After 12 weeks, more people using adapalene/benzoyl peroxide had clear or almost clear skin compared to people using the other treatments. Similar results were seen in studies involving younger individuals (as young as nine years old).

Adapalene/Benzoyl Peroxide Drug Information

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