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Drugs That Can Interfere With Acitretin

Alcohol
Alcohol can change acitretin into a different medication that lasts much longer in the body. If you consume any alcohol while taking acitretin or within two months of stopping the medication, acitretin may stay in the body for more than three years (instead of the normal time of about two months).
 
This is most important for women, who must avoid pregnancy while taking acitretin and for a certain period of time afterwards, due to the risk of severe birth defects (see Soriatane and Pregnancy). Women of childbearing potential (all women, except those who have had a hysterectomy or those who have definitely been through menopause) must avoid all alcohol while taking acitretin and for two months afterward. This includes any form of alcohol, including alcohol in food, beverages, or even medications.
 
Diabetes Medications
It is possible that acitretin may affect your blood sugar level. Check with your healthcare provider before combining acitretin with a diabetes medication. You may need to monitor your blood sugar level more closely, and your healthcare provider might need to adjust the dosage of your diabetes medication.
 
Isotretinoin
Acitretin and isotretinoin (a similar retinoid medication) should not be taken together, as this may increase the risk of vitamin A toxicity symptoms.
 
Methotrexate
Combining methotrexate with acitretin may increase the risk of hepatitis, and this drug combination should be avoided.
 
Phenytoin
Combining phenytoin with acitretin might change how the body handles phenytoin. Your healthcare provider should measure your phenytoin levels, and your phenytoin dosage may need to be adjusted.

Acitretin Drug Information

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